<?xml version='1.0' encoding='UTF-8' standalone='no'?>
<sbml xmlns="http://www.sbml.org/sbml/level2/version4" level="2" metaid="_350618" version="4">
  <model id="MAPK_in_Solution" name="Levchenko2000_MAPK_noScaffold" metaid="_350630">
    <notes>
      <body xmlns="http://www.w3.org/1999/xhtml">
        <h1>MAPK cascade in solution (no scaffold)</h1>
            <table border="0" cellpadding="2" cellspacing="0">      <thead>        <tr>          <th align="left" bgcolor="#eeeeee" valign="middle">Description</th>
                        </tr>
                    </thead>
                <tbody>        <tr>          <td>This model describes a basic 3-
							stage Mitogen Activated Protein Kinase (MAPK)
							 cascade in solution. This cascade is typically expressed as RAF=
							=>MEK==>MAPK (alternative forms are K3==>K2==>
							K1 and KKK==>KK==>K)
							. The input signal is RAFK (RAF Kinase)
							 and the output signal is MAPKpp (
							doubly phosphorylated form of MAPK)
							.  RAFK phosphorylates RAF once to RAFp.  RAFp,
							 the phosphorylated form of RAF induces two phoshporylations of MEK,
							to MEKp and MEKpp. MEKpp,
							 the doubly phosphorylated form of MEK,
							 induces two phosphorylations of MAPK to MAPKp and MAPKpp.</td>
                        </tr>
                    </tbody>
                </table>
            <table border="0" cellpadding="2" cellspacing="0">      <thead>        <tr>          <th align="left" bgcolor="#eeeeee" valign="middle">Rate constant      </th>
                        <th align="left" bgcolor="#eeeeee" valign="middle">Reaction</th>
                        </tr>
                    </thead>
                <tbody>        <tr>          <td>a10 = 5.</td>
                        <td>MAPKPH + MAPKpp -> MAPKppMAPKPH</td>
                        </tr>
                    <tr>          <td>a1 = 1.</td>
                        <td>RAF + RAFK -> RAFRAFK</td>
                        </tr>
                    <tr>          <td>a2 = 0.5</td>
                        <td>RAFp + RAFPH -> RAFpRAFPH</td>
                        </tr>
                    <tr>          <td>a3 = 3.3</td>
                        <td>MEK + RAFp -> MEKRAFp</td>
                        </tr>
                    <tr>          <td>a4 = 10.</td>
                        <td>MEKp + MEKPH -> MEKpMEKPH</td>
                        </tr>
                    <tr>          <td>a5 = 3.3</td>
                        <td>MEKp + RAFp -> MEKpRAFp</td>
                        </tr>
                    <tr>          <td>a6 = 10.</td>
                        <td>MEKPH + MEKpp -> MEKppMEKPH</td>
                        </tr>
                    <tr>          <td>a7 = 20.</td>
                        <td>MAPK + MEKpp -> MAPKMEKpp</td>
                        </tr>
                    <tr>          <td>a8 = 5.</td>
                        <td>MAPKp + MAPKPH -> MAPKpMAPKPH</td>
                        </tr>
                    <tr>          <td>a9 = 20.</td>
                        <td>MAPKp + MEKpp -> MAPKpMEKpp</td>
                        </tr>
                    <tr>          <td>d10 = 0.4</td>
                        <td>MAPKppMAPKPH -> MAPKPH + MAPKpp</td>
                        </tr>
                    <tr>          <td>d1 = 0.4</td>
                        <td>RAFRAFK -> RAF + RAFK</td>
                        </tr>
                    <tr>          <td>d2 = 0.5</td>
                        <td>RAFpRAFPH -> RAFp + RAFPH</td>
                        </tr>
                    <tr>          <td>d3 = 0.42</td>
                        <td>MEKRAFp -> MEK + RAFp</td>
                        </tr>
                    <tr>          <td>d4 = 0.8</td>
                        <td>MEKpMEKPH -> MEKp + MEKPH</td>
                        </tr>
                    <tr>          <td>d5 = 0.4</td>
                        <td>MEKpRAFp -> MEKp + RAFp</td>
                        </tr>
                    <tr>          <td>d6 = 0.8</td>
                        <td>MEKppMEKPH -> MEKPH + MEKpp</td>
                        </tr>
                    <tr>          <td>d7 = 0.6</td>
                        <td>MAPKMEKpp -> MAPK + MEKpp</td>
                        </tr>
                    <tr>          <td>d8 = 0.4</td>
                        <td>MAPKpMAPKPH -> MAPKp + MAPKPH</td>
                        </tr>
                    <tr>          <td>d9 = 0.6</td>
                        <td>MAPKpMEKpp -> MAPKp + MEKpp</td>
                        </tr>
                    <tr>          <td>k10 = 0.1</td>
                        <td>MAPKppMAPKPH -> MAPKp + MAPKPH</td>
                        </tr>
                    <tr>          <td>k1 = 0.1</td>
                        <td>RAFRAFK -> RAFK + RAFp</td>
                        </tr>
                    <tr>          <td>k2 = 0.1</td>
                        <td>RAFpRAFPH -> RAF + RAFPH</td>
                        </tr>
                    <tr>          <td>k3 = 0.1</td>
                        <td>MEKRAFp -> MEKp + RAFp</td>
                        </tr>
                    <tr>          <td>k4 = 0.1</td>
                        <td>MEKpMEKPH -> MEK + MEKPH</td>
                        </tr>
                    <tr>          <td>k5 = 0.1</td>
                        <td>MEKpRAFp -> MEKpp + RAFp</td>
                        </tr>
                    <tr>          <td>k6 = 0.1</td>
                        <td>MEKppMEKPH -> MEKp + MEKPH</td>
                        </tr>
                    <tr>          <td>k7 = 0.1</td>
                        <td>MAPKMEKpp -> MAPKp + MEKpp</td>
                        </tr>
                    <tr>          <td>k8 = 0.1</td>
                        <td>MAPKpMAPKPH -> MAPK + MAPKPH</td>
                        </tr>
                    <tr>          <td>k9 = 0.1</td>
                        <td>MAPKpMEKpp -> MAPKpp + MEKpp</td>
                        </tr>
                    </tbody>
                </table>
            <table border="0" cellpadding="2" cellspacing="0">      <thead>        <tr>          <th align="left" bgcolor="#eeeeee" valign="middle">Variable</th>
                        <th align="left" bgcolor="#eeeeee" valign="middle">IC  </th>
                        <th align="left" bgcolor="#eeeeee" valign="middle">ODE</th>
                        </tr>
                    </thead>
                <tbody>        <tr>          <td>MAPK</td>
                        <td>0.3</td>
                        <td>MAPK'[t] == d7*MAPKMEKpp[t] + k8*MAPKpMAPKPH[t] -
							 a7*MAPK[t]*MEKpp[t]</td>
                        </tr>
                    <tr>          <td>MAPKMEKpp</td>
                        <td>0</td>
                        <td>MAPKMEKpp'[t] == -(d7*MAPKMEKpp[t]) - k7*MAPKMEKpp[t]
							 + a7*MAPK[t]*MEKpp[t]</td>
                        </tr>
                    <tr>          <td>MAPKp</td>
                        <td>0</td>
                        <td>MAPKp'[t] == k7*MAPKMEKpp[t] - a8*MAPKp[t]*MAPKPH[t]
							 + d8*MAPKpMAPKPH[t] + d9*MAPKpMEKpp[t] + k10*
							MAPKppMAPKPH[t] - a9*MAPKp[t]*MEKpp[t]</td>
                        </tr>
                    <tr>          <td>MAPKPH</td>
                        <td>0.3</td>
                        <td>MAPKPH'[t] == -(a8*MAPKp[t]*MAPKPH[t]) + d8*MAPKpMAPKPH[
							t] + k8*MAPKpMAPKPH[t] - a10*MAPKPH[t]*MAPKpp[t] +
							 d10*MAPKppMAPKPH[t] + k10*MAPKppMAPKPH[t]</td>
                        </tr>
                    <tr>          <td>MAPKpMAPKPH</td>
                        <td>0</td>
                        <td>MAPKpMAPKPH'[t] == a8*MAPKp[t]*MAPKPH[t] - d8*
							MAPKpMAPKPH[t] - k8*MAPKpMAPKPH[t]</td>
                        </tr>
                    <tr>          <td>MAPKpMEKpp</td>
                        <td>0</td>
                        <td>MAPKpMEKpp'[t] == -(d9*MAPKpMEKpp[t]) - k9*MAPKpMEKpp[t]
							 + a9*MAPKp[t]*MEKpp[t]</td>
                        </tr>
                    <tr>          <td>MAPKpp</td>
                        <td>0</td>
                        <td>MAPKpp'[t] == k9*MAPKpMEKpp[t] - a10*MAPKPH[t]*MAPKpp[t]
							 + d10*MAPKppMAPKPH[t]</td>
                        </tr>
                    <tr>          <td>MAPKppMAPKPH</td>
                        <td>0</td>
                        <td>MAPKppMAPKPH'[t] == a10*MAPKPH[t]*MAPKpp[t] - d10*
							MAPKppMAPKPH[t] - k10*MAPKppMAPKPH[t]</td>
                        </tr>
                    <tr>          <td>MEK</td>
                        <td>0.2</td>
                        <td>MEK'[t] == k4*MEKpMEKPH[t] + d3*MEKRAFp[t] -
							 a3*MEK[t]*RAFp[t]</td>
                        </tr>
                    <tr>          <td>MEKp</td>
                        <td>0</td>
                        <td>MEKp'[t] == -(a4*MEKp[t]*MEKPH[t]) + d4*MEKpMEKPH[t]
							 + k6*MEKppMEKPH[t] + d5*MEKpRAFp[t] + k3*MEKRAFp[
							t] - a5*MEKp[t]*RAFp[t]</td>
                        </tr>
                    <tr>          <td>MEKPH</td>
                        <td>0.2</td>
                        <td>MEKPH'[t] == -(a4*MEKp[t]*MEKPH[t]) + d4*MEKpMEKPH[t]
							 + k4*MEKpMEKPH[t] - a6*MEKPH[t]*MEKpp[t] + d6*
							MEKppMEKPH[t] + k6*MEKppMEKPH[t]</td>
                        </tr>
                    <tr>          <td>MEKpMEKPH</td>
                        <td>0</td>
                        <td>MEKpMEKPH'[t] == a4*MEKp[t]*MEKPH[t] - d4*MEKpMEKPH[t]
							 - k4*MEKpMEKPH[t]</td>
                        </tr>
                    <tr>          <td>MEKpp</td>
                        <td>0</td>
                        <td>MEKpp'[t] == d7*MAPKMEKpp[t] + k7*MAPKMEKpp[t] +
							 d9*MAPKpMEKpp[t] + k9*MAPKpMEKpp[t] - a7*MAPK[t]*
							MEKpp[t] - a9*MAPKp[t]*MEKpp[t] - a6*MEKPH[t]*MEKpp[t]
							 + d6*MEKppMEKPH[t] + k5*MEKpRAFp[t]</td>
                        </tr>
                    <tr>          <td>MEKppMEKPH</td>
                        <td>0</td>
                        <td>MEKppMEKPH'[t] == a6*MEKPH[t]*MEKpp[t] - d6*MEKppMEKPH[
							t] - k6*MEKppMEKPH[t]</td>
                        </tr>
                    <tr>          <td>MEKpRAFp</td>
                        <td>0</td>
                        <td>MEKpRAFp'[t] == -(d5*MEKpRAFp[t]) - k5*MEKpRAFp[t]
							 + a5*MEKp[t]*RAFp[t]</td>
                        </tr>
                    <tr>          <td>MEKRAFp</td>
                        <td>0</td>
                        <td>MEKRAFp'[t] == -(d3*MEKRAFp[t]) - k3*MEKRAFp[t] +
							 a3*MEK[t]*RAFp[t]</td>
                        </tr>
                    <tr>          <td>RAF</td>
                        <td>0.4</td>
                        <td>RAF'[t] == -(a1*RAF[t]*RAFK[t]) + k2*RAFpRAFPH[t] +
							 d1*RAFRAFK[t]</td>
                        </tr>
                    <tr>          <td>RAFK</td>
                        <td>0.1</td>
                        <td>RAFK'[t] == -(a1*RAF[t]*RAFK[t]) + d1*RAFRAFK[t] +
							 k1*RAFRAFK[t]</td>
                        </tr>
                    <tr>          <td>RAFp</td>
                        <td>0</td>
                        <td>RAFp'[t] == d5*MEKpRAFp[t] + k5*MEKpRAFp[t] +
							 d3*MEKRAFp[t] + k3*MEKRAFp[t] - a3*MEK[t]*RAFp[t]
							 - a5*MEKp[t]*RAFp[t] - a2*RAFp[t]*RAFPH[t] + d2*
							RAFpRAFPH[t] + k1*RAFRAFK[t]</td>
                        </tr>
                    <tr>          <td>RAFPH</td>
                        <td>0.3</td>
                        <td>RAFPH'[t] == -(a2*RAFp[t]*RAFPH[t]) + d2*RAFpRAFPH[t]
							 + k2*RAFpRAFPH[t]</td>
                        </tr>
                    <tr>          <td>RAFpRAFPH</td>
                        <td>0</td>
                        <td>RAFpRAFPH'[t] == a2*RAFp[t]*RAFPH[t] - d2*RAFpRAFPH[t]
							 - k2*RAFpRAFPH[t]</td>
                        </tr>
                    <tr>          <td>RAFRAFK</td>
                        <td>0</td>
                        <td>RAFRAFK'[t] == a1*RAF[t]*RAFK[t] - d1*RAFRAFK[t] -
							 k1*RAFRAFK[t]</td>
                        </tr>
                    </tbody>
                </table>
            <p>Generated by Cellerator Version 1.4.3 (6-March-2004) using Mathematica 5.0 
				for Mac OS X (November 19, 2003), March 6, 2004 12:18:07, using (PowerMac,
				PowerPC,Mac OS X,MacOSX,Darwin)</p>
            <p>author=B.E.Shapiro</p>
            <p>This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2010 The BioModels.net Team.      <br/>
          For more information see the      <a href="http://www.ebi.ac.uk/biomodels/legal.html" target="_blank">terms of use</a>
          .      <br/>
          To cite BioModels Database, please use:      <a href="http://www.ncbi.nlm.nih.gov/pubmed/20587024" target="_blank">Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.</a>
                </p>
            </body>
      
    </notes>
    <annotation>
      <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
        <rdf:Description rdf:about="#_350630">
          <dc:creator>
            <rdf:Bag>
              <rdf:li rdf:parseType="Resource">
                <vCard:N rdf:parseType="Resource">
                  <vCard:Family>Shapiro</vCard:Family>
                  <vCard:Given>Bruce</vCard:Given>
                </vCard:N>
                <vCard:EMAIL>bshapiro@jpl.nasa.gov</vCard:EMAIL>
                <vCard:ORG rdf:parseType="Resource">
                  <vCard:Orgname>NASA Jet Propulsion Laboratory</vCard:Orgname>
                </vCard:ORG>
              </rdf:li>
            </rdf:Bag>
          </dc:creator>
          <dcterms:created rdf:parseType="Resource">
            <dcterms:W3CDTF>2005-02-15T00:12:30Z</dcterms:W3CDTF>
          </dcterms:created>
          <dcterms:modified rdf:parseType="Resource">
            <dcterms:W3CDTF>2012-05-15T15:47:52Z</dcterms:W3CDTF>
          </dcterms:modified>
          <bqmodel:is>
            <rdf:Bag>
              <rdf:li rdf:resource="http://identifiers.org/biomodels.db/MODEL6615234250"/>
            </rdf:Bag>
          </bqmodel:is>
          <bqmodel:is>
            <rdf:Bag>
              <rdf:li rdf:resource="http://identifiers.org/biomodels.db/BIOMD0000000011"/>
            </rdf:Bag>
          </bqmodel:is>
          <bqmodel:isDescribedBy>
            <rdf:Bag>
              <rdf:li rdf:resource="http://identifiers.org/pubmed/10823939"/>
            </rdf:Bag>
          </bqmodel:isDescribedBy>
          <bqbiol:isHomologTo>
            <rdf:Bag>
              <rdf:li rdf:resource="http://identifiers.org/reactome/REACT_634"/>
            </rdf:Bag>
          </bqbiol:isHomologTo>
          <bqbiol:isVersionOf>
            <rdf:Bag>
              <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0000165"/>
            </rdf:Bag>
          </bqbiol:isVersionOf>
          <bqbiol:occursIn>
            <rdf:Bag>
              <rdf:li rdf:resource="http://identifiers.org/taxonomy/8355"/>
            </rdf:Bag>
          </bqbiol:occursIn>
        </rdf:Description>
      </rdf:RDF>
    </annotation>
      <listOfUnitDefinitions>
      <unitDefinition id="substance" name="micromole" metaid="metaid_0000030">
        <listOfUnits>
          <unit scale="-6" metaid="_571210" kind="mole"/>
        </listOfUnits>
      </unitDefinition>
    </listOfUnitDefinitions>
    <listOfCompartments>
      <compartment id="Cytoplasm" metaid="_191248" size="1">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_191248">
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0005737"/>
                </rdf:Bag>
              </bqbiol:is>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
      </compartment>
    </listOfCompartments>
    <listOfSpecies>
      <species id="MAPK" initialAmount="0.4" hasOnlySubstanceUnits="true" name="MAPK" metaid="_191261" compartment="Cytoplasm">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_191261">
              <bqbiol:isVersionOf>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/uniprot/P26696"/>
                </rdf:Bag>
              </bqbiol:isVersionOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
      </species>
      <species id="MAPKMEKpp" initialAmount="0" hasOnlySubstanceUnits="true" name="MAPK_MEK-PP" metaid="_191281" compartment="Cytoplasm">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_191281">
              <bqbiol:hasPart>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/uniprot/P26696"/>
                  <rdf:li rdf:resource="http://identifiers.org/uniprot/Q05116"/>
                </rdf:Bag>
              </bqbiol:hasPart>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
      </species>
      <species id="MAPKp" initialAmount="0" hasOnlySubstanceUnits="true" name="MAPK-P" metaid="_191301" compartment="Cytoplasm">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_191301">
              <bqbiol:isVersionOf>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/uniprot/P26696"/>
                </rdf:Bag>
              </bqbiol:isVersionOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
      </species>
      <species id="MAPKPH" initialAmount="0.3" hasOnlySubstanceUnits="true" name="MAPK phosphatase" metaid="_191321" compartment="Cytoplasm">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_191321">
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/uniprot/Q90W58"/>
                </rdf:Bag>
              </bqbiol:is>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
      </species>
      <species id="MAPKpMAPKPH" initialAmount="0" hasOnlySubstanceUnits="true" name="MAPK-P_MAPKPase" metaid="_191341" compartment="Cytoplasm">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_191341">
              <bqbiol:hasPart>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/uniprot/P26696"/>
                  <rdf:li rdf:resource="http://identifiers.org/uniprot/Q90W58"/>
                </rdf:Bag>
              </bqbiol:hasPart>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
      </species>
      <species id="MAPKpMEKpp" initialAmount="0" hasOnlySubstanceUnits="true" name="MAPK-P_MEK-PP" metaid="_191361" compartment="Cytoplasm">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_191361">
              <bqbiol:hasPart>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/uniprot/Q05116"/>
                  <rdf:li rdf:resource="http://identifiers.org/uniprot/P26696"/>
                </rdf:Bag>
              </bqbiol:hasPart>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
      </species>
      <species id="MAPKpp" initialAmount="0" hasOnlySubstanceUnits="true" name="MAPK-PP" metaid="_191381" compartment="Cytoplasm">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_191381">
              <bqbiol:isVersionOf>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/uniprot/P26696"/>
                </rdf:Bag>
              </bqbiol:isVersionOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
      </species>
      <species id="MAPKppMAPKPH" initialAmount="0" hasOnlySubstanceUnits="true" name="MAPK-PP_MAPKPase" metaid="_191401" compartment="Cytoplasm">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_191401">
              <bqbiol:hasPart>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/uniprot/P26696"/>
                  <rdf:li rdf:resource="http://identifiers.org/uniprot/Q90W58"/>
                </rdf:Bag>
              </bqbiol:hasPart>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
      </species>
      <species id="MEK" initialAmount="0.2" hasOnlySubstanceUnits="true" name="MEK" metaid="_191421" compartment="Cytoplasm">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_191421">
              <bqbiol:isVersionOf>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/uniprot/Q05116"/>
                </rdf:Bag>
              </bqbiol:isVersionOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
      </species>
      <species id="MEKp" initialAmount="0" hasOnlySubstanceUnits="true" name="MEK-P" metaid="_191441" compartment="Cytoplasm">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_191441">
              <bqbiol:isVersionOf>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/uniprot/Q05116"/>
                </rdf:Bag>
              </bqbiol:isVersionOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
      </species>
      <species id="MEKPH" initialAmount="0.2" hasOnlySubstanceUnits="true" name="MEK phosphatase" metaid="_191461" compartment="Cytoplasm"/>
      <species id="MEKpMEKPH" initialAmount="0" hasOnlySubstanceUnits="true" name="MEK-P_MEKPase" metaid="_191481" compartment="Cytoplasm">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_191481">
              <bqbiol:hasPart>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/uniprot/Q05116"/>
                </rdf:Bag>
              </bqbiol:hasPart>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
      </species>
      <species id="MEKpp" initialAmount="0" hasOnlySubstanceUnits="true" name="MEK-PP" metaid="_191501" compartment="Cytoplasm">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_191501">
              <bqbiol:isVersionOf>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/uniprot/Q05116"/>
                </rdf:Bag>
              </bqbiol:isVersionOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
      </species>
      <species id="MEKppMEKPH" initialAmount="0" hasOnlySubstanceUnits="true" name="MEK-PP_MEKPase" metaid="_191521" compartment="Cytoplasm">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_191521">
              <bqbiol:hasPart>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/uniprot/Q05116"/>
                </rdf:Bag>
              </bqbiol:hasPart>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
      </species>
      <species id="MEKpRAFp" initialAmount="0" hasOnlySubstanceUnits="true" name="MEK-P_RAF-P" metaid="_191541" compartment="Cytoplasm">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_191541">
              <bqbiol:hasPart>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/uniprot/P09560"/>
                  <rdf:li rdf:resource="http://identifiers.org/uniprot/Q05116"/>
                </rdf:Bag>
              </bqbiol:hasPart>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
      </species>
      <species id="MEKRAFp" initialAmount="0" hasOnlySubstanceUnits="true" name="MEK_RAF-P" metaid="_191561" compartment="Cytoplasm">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_191561">
              <bqbiol:hasPart>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/uniprot/P09560"/>
                  <rdf:li rdf:resource="http://identifiers.org/uniprot/Q05116"/>
                </rdf:Bag>
              </bqbiol:hasPart>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
      </species>
      <species id="RAF" initialAmount="0.3" hasOnlySubstanceUnits="true" name="RAF" metaid="_191581" compartment="Cytoplasm">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_191581">
              <bqbiol:isVersionOf>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/uniprot/P09560"/>
                </rdf:Bag>
              </bqbiol:isVersionOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
      </species>
      <species id="RAFK" initialAmount="0.2" hasOnlySubstanceUnits="true" name="RAFK" metaid="_191601" compartment="Cytoplasm">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_191601">
              <bqbiol:isVersionOf>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/interpro/IPR003577"/>
                </rdf:Bag>
              </bqbiol:isVersionOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
      </species>
      <species id="RAFp" initialAmount="0" hasOnlySubstanceUnits="true" name="RAF-P" metaid="_191621" compartment="Cytoplasm">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_191621">
              <bqbiol:isVersionOf>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/uniprot/P09560"/>
                </rdf:Bag>
              </bqbiol:isVersionOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
      </species>
      <species id="RAFPH" initialAmount="0.3" hasOnlySubstanceUnits="true" name="RAF phosphatase" metaid="_191641" compartment="Cytoplasm"/>
      <species id="RAFpRAFPH" initialAmount="0" hasOnlySubstanceUnits="true" name="RAF-P_RAFPase" metaid="_191661" compartment="Cytoplasm">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_191661">
              <bqbiol:hasPart>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/uniprot/P09560"/>
                </rdf:Bag>
              </bqbiol:hasPart>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
      </species>
      <species id="RAFRAFK" initialAmount="0" hasOnlySubstanceUnits="true" name="RAF_RAFK" metaid="_191681" compartment="Cytoplasm">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_191681">
              <bqbiol:hasPart>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/uniprot/P09560"/>
                  <rdf:li rdf:resource="http://identifiers.org/interpro/IPR003577"/>
                </rdf:Bag>
              </bqbiol:hasPart>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
      </species>
    </listOfSpecies>
    <listOfReactions>
      <reaction id="Reaction1" name="binding of RAF and RAFK" metaid="_191702" reversible="false">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_191702">
              <bqbiol:isHomologTo>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/reactome/REACT_996"/>
                </rdf:Bag>
              </bqbiol:isHomologTo>
              <bqbiol:isVersionOf>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0031435"/>
                </rdf:Bag>
              </bqbiol:isVersionOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
              <listOfReactants>
          <speciesReference species="RAF" metaid="_571223"/>
          <speciesReference species="RAFK" metaid="_571235"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="RAFRAFK" metaid="_571248"/>
        </listOfProducts>
        <kineticLaw metaid="_571260">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> a1 </ci>
              <ci> RAF </ci>
              <ci> RAFK </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="a1" metaid="_972035" value="1"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="Reaction2" name="dissociation of RAF_RAFK" metaid="_191722" reversible="false">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_191722">
              <bqbiol:isVersionOf>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0043241"/>
                </rdf:Bag>
              </bqbiol:isVersionOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
              <listOfReactants>
          <speciesReference species="RAFRAFK" metaid="_571272"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="RAF" metaid="_571284"/>
          <speciesReference species="RAFK" metaid="_571296"/>
        </listOfProducts>
        <kineticLaw metaid="_571308">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> d1 </ci>
              <ci> RAFRAFK </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="d1" metaid="_972037" value="0.4"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="Reaction3" name="phosphorylation of RAF" metaid="_191743" reversible="false">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_191743">
              <bqbiol:isVersionOf>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/ec-code/2.7.11.1"/>
                  <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0008349"/>
                  <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0000185"/>
                  <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0006468"/>
                </rdf:Bag>
              </bqbiol:isVersionOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
              <listOfReactants>
          <speciesReference species="RAFRAFK" metaid="_571320"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="RAFK" metaid="_571332"/>
          <speciesReference species="RAFp" metaid="_571345"/>
        </listOfProducts>
        <kineticLaw metaid="_571357">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> k1 </ci>
              <ci> RAFRAFK </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="k1" metaid="_972039" value="0.1"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="Reaction4" name="binding of RAF-P and RAF phosphatase" metaid="_191763" reversible="false">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_191763">
              <bqbiol:isVersionOf>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0031435"/>
                </rdf:Bag>
              </bqbiol:isVersionOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
              <listOfReactants>
          <speciesReference species="RAFp" metaid="_571369"/>
          <speciesReference species="RAFPH" metaid="_571381"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="RAFpRAFPH" metaid="_571393"/>
        </listOfProducts>
        <kineticLaw metaid="_571405">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> a2 </ci>
              <ci> RAFp </ci>
              <ci> RAFPH </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="a2" metaid="_972041" value="0.5"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="Reaction5" name="dissociation of RAF-P_RAFPase" metaid="_191783" reversible="false">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_191783">
              <bqbiol:isVersionOf>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0043241"/>
                </rdf:Bag>
              </bqbiol:isVersionOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
              <listOfReactants>
          <speciesReference species="RAFpRAFPH" metaid="_571418"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="RAFp" metaid="_571430"/>
          <speciesReference species="RAFPH" metaid="_571442"/>
        </listOfProducts>
        <kineticLaw metaid="_571454">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> d2 </ci>
              <ci> RAFpRAFPH </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="d2" metaid="_972043" value="0.5"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="Reaction6" name="dephosphorylation of RAF-P" metaid="_191803" reversible="false">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_191803">
              <bqbiol:isVersionOf>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/ec-code/3.1.3.16"/>
                  <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0051390"/>
                  <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0006470"/>
                </rdf:Bag>
              </bqbiol:isVersionOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
              <listOfReactants>
          <speciesReference species="RAFpRAFPH" metaid="_571466"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="RAF" metaid="_571478"/>
          <speciesReference species="RAFPH" metaid="_571490"/>
        </listOfProducts>
        <kineticLaw metaid="_571503">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> k2 </ci>
              <ci> RAFpRAFPH </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="k2" metaid="_972045" value="0.1"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="Reaction7" name="binding of MEK and RAF-P" metaid="_191823" reversible="false">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_191823">
              <bqbiol:isHomologTo>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/reactome/REACT_143"/>
                </rdf:Bag>
              </bqbiol:isHomologTo>
              <bqbiol:isVersionOf>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0031434"/>
                  <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0031435"/>
                </rdf:Bag>
              </bqbiol:isVersionOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
              <listOfReactants>
          <speciesReference species="MEK" metaid="_571516"/>
          <speciesReference species="RAFp" metaid="_571528"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="MEKRAFp" metaid="_571541"/>
        </listOfProducts>
        <kineticLaw metaid="_571554">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> a3 </ci>
              <ci> MEK </ci>
              <ci> RAFp </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="a3" metaid="_972047" value="3.3"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="Reaction8" name="dissociation of MEK_RAF-P" metaid="_191843" reversible="false">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_191843">
              <bqbiol:isVersionOf>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0043241"/>
                </rdf:Bag>
              </bqbiol:isVersionOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
              <listOfReactants>
          <speciesReference species="MEKRAFp" metaid="_571567"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="MEK" metaid="_571580"/>
          <speciesReference species="RAFp" metaid="_571593"/>
        </listOfProducts>
        <kineticLaw metaid="_571606">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> d3 </ci>
              <ci> MEKRAFp </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="d3" metaid="_972049" value="0.42"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="Reaction9" name="phosphorylation of MEK" metaid="_191862" reversible="false">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_191862">
              <bqbiol:isHomologTo>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/reactome/REACT_614"/>
                </rdf:Bag>
              </bqbiol:isHomologTo>
              <bqbiol:isVersionOf>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/ec-code/2.7.11.25"/>
                  <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0004709"/>
                  <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0006468"/>
                </rdf:Bag>
              </bqbiol:isVersionOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
              <listOfReactants>
          <speciesReference species="MEKRAFp" metaid="_571620"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="MEKp" metaid="_571633"/>
          <speciesReference species="RAFp" metaid="_571646"/>
        </listOfProducts>
        <kineticLaw metaid="_571660">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> k3 </ci>
              <ci> MEKRAFp </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="k3" metaid="_972051" value="0.1"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="Reaction10" name="binding of MEK-P and MEK phosphatase" metaid="_191883" reversible="false">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_191883">
              <bqbiol:isVersionOf>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0031434"/>
                </rdf:Bag>
              </bqbiol:isVersionOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
              <listOfReactants>
          <speciesReference species="MEKp" metaid="_571673"/>
          <speciesReference species="MEKPH" metaid="_571686"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="MEKpMEKPH" metaid="_571699"/>
        </listOfProducts>
        <kineticLaw metaid="_571712">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> a4 </ci>
              <ci> MEKp </ci>
              <ci> MEKPH </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="a4" metaid="_972053" value="10"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="Reaction11" name="dissociation of MEK-P_MEKPase" metaid="_191902" reversible="false">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_191902">
              <bqbiol:isVersionOf>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0043241"/>
                </rdf:Bag>
              </bqbiol:isVersionOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
              <listOfReactants>
          <speciesReference species="MEKpMEKPH" metaid="_571725"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="MEKp" metaid="_571738"/>
          <speciesReference species="MEKPH" metaid="_571751"/>
        </listOfProducts>
        <kineticLaw metaid="_571764">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> d4 </ci>
              <ci> MEKpMEKPH </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="d4" metaid="_972055" value="0.8"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="Reaction12" name="dephosphorylation of MEK-P" metaid="_191923" reversible="false">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_191923">
              <bqbiol:isVersionOf>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/ec-code/3.1.3.16"/>
                  <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0006470"/>
                </rdf:Bag>
              </bqbiol:isVersionOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
              <listOfReactants>
          <speciesReference species="MEKpMEKPH" metaid="_571778"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="MEK" metaid="_571791"/>
          <speciesReference species="MEKPH" metaid="_571804"/>
        </listOfProducts>
        <kineticLaw metaid="_571817">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> k4 </ci>
              <ci> MEKpMEKPH </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="k4" metaid="_972057" value="0.1"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="Reaction13" name="binding of MEK-P and RAF-P" metaid="_191943" reversible="false">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_191943">
              <bqbiol:isHomologTo>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/reactome/REACT_143"/>
                </rdf:Bag>
              </bqbiol:isHomologTo>
              <bqbiol:isVersionOf>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0031435"/>
                  <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0031434"/>
                </rdf:Bag>
              </bqbiol:isVersionOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
              <listOfReactants>
          <speciesReference species="MEKp" metaid="_571831"/>
          <speciesReference species="RAFp" metaid="_571844"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="MEKpRAFp" metaid="_571857"/>
        </listOfProducts>
        <kineticLaw metaid="_571870">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> a5 </ci>
              <ci> MEKp </ci>
              <ci> RAFp </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="a5" metaid="_972059" value="3.3"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="Reaction14" name="dissociation of MEK-P_RAF-P" metaid="_191962" reversible="false">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_191962">
              <bqbiol:isVersionOf>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0043241"/>
                </rdf:Bag>
              </bqbiol:isVersionOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
              <listOfReactants>
          <speciesReference species="MEKpRAFp" metaid="_571883"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="MEKp" metaid="_571896"/>
          <speciesReference species="RAFp" metaid="_571909"/>
        </listOfProducts>
        <kineticLaw metaid="_571922">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> d5 </ci>
              <ci> MEKpRAFp </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="d5" metaid="_972061" value="0.4"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="Reaction15" name="phosphorylation of MEK-P" metaid="_191983" reversible="false">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_191983">
              <bqbiol:isHomologTo>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/reactome/REACT_614"/>
                </rdf:Bag>
              </bqbiol:isHomologTo>
              <bqbiol:isVersionOf>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/ec-code/2.7.11.25"/>
                  <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0006468"/>
                  <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0004709"/>
                  <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0000186"/>
                </rdf:Bag>
              </bqbiol:isVersionOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
              <listOfReactants>
          <speciesReference species="MEKpRAFp" metaid="_571935"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="MEKpp" metaid="_571948"/>
          <speciesReference species="RAFp" metaid="_571961"/>
        </listOfProducts>
        <kineticLaw metaid="_571974">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> k5 </ci>
              <ci> MEKpRAFp </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="k5" metaid="_972063" value="0.1"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="Reaction16" name="binding of MEK-PP and MEK phosphatase" metaid="_192002" reversible="false">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_192002">
              <bqbiol:isVersionOf>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0031434"/>
                </rdf:Bag>
              </bqbiol:isVersionOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
              <listOfReactants>
          <speciesReference species="MEKPH" metaid="_571987"/>
          <speciesReference species="MEKpp" metaid="_572000"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="MEKppMEKPH" metaid="_572013"/>
        </listOfProducts>
        <kineticLaw metaid="_572027">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> a6 </ci>
              <ci> MEKPH </ci>
              <ci> MEKpp </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="a6" metaid="_972065" value="10"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="Reaction17" name="dissociation of MEK-PP_MEKPase" metaid="_192022" reversible="false">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_192022">
              <bqbiol:isVersionOf>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0043241"/>
                </rdf:Bag>
              </bqbiol:isVersionOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
              <listOfReactants>
          <speciesReference species="MEKppMEKPH" metaid="_572040"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="MEKPH" metaid="_572053"/>
          <speciesReference species="MEKpp" metaid="_572066"/>
        </listOfProducts>
        <kineticLaw metaid="_572079">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> d6 </ci>
              <ci> MEKppMEKPH </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="d6" metaid="_972067" value="0.8"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="Reaction18" name="dephosphorylation of MEK-PP" metaid="_192042" reversible="false">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_192042">
              <bqbiol:isVersionOf>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/ec-code/3.1.3.16"/>
                  <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0051389"/>
                  <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0006470"/>
                </rdf:Bag>
              </bqbiol:isVersionOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
              <listOfReactants>
          <speciesReference species="MEKppMEKPH" metaid="_572092"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="MEKp" metaid="_572105"/>
          <speciesReference species="MEKPH" metaid="_572118"/>
        </listOfProducts>
        <kineticLaw metaid="_572131">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> k6 </ci>
              <ci> MEKppMEKPH </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="k6" metaid="_972069" value="0.1"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="Reaction19" name="binding of MAPK and MEK-PP" metaid="_192063" reversible="false">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_192063">
              <bqbiol:isHomologTo>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/reactome/REACT_495"/>
                  <rdf:li rdf:resource="http://identifiers.org/reactome/REACT_1780"/>
                </rdf:Bag>
              </bqbiol:isHomologTo>
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0051019"/>
                  <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0031434"/>
                </rdf:Bag>
              </bqbiol:is>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
              <listOfReactants>
          <speciesReference species="MAPK" metaid="_572143"/>
          <speciesReference species="MEKpp" metaid="_572155"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="MAPKMEKpp" metaid="_572167"/>
        </listOfProducts>
        <kineticLaw metaid="_572180">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> a7 </ci>
              <ci> MAPK </ci>
              <ci> MEKpp </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="a7" metaid="_972071" value="20"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="Reaction20" name="dissociation of MAPK_MEK-PP" metaid="_192083" reversible="false">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_192083">
              <bqbiol:isVersionOf>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0043241"/>
                </rdf:Bag>
              </bqbiol:isVersionOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
              <listOfReactants>
          <speciesReference species="MAPKMEKpp" metaid="_572192"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="MAPK" metaid="_572204"/>
          <speciesReference species="MEKpp" metaid="_572216"/>
        </listOfProducts>
        <kineticLaw metaid="_572228">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> d7 </ci>
              <ci> MAPKMEKpp </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="d7" metaid="_972073" value="0.6"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="Reaction21" name="phosphorylation of MAPK" metaid="_192102" reversible="false">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_192102">
              <bqbiol:isHomologTo>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/reactome/REACT_2247"/>
                  <rdf:li rdf:resource="http://identifiers.org/reactome/REACT_136"/>
                </rdf:Bag>
              </bqbiol:isHomologTo>
              <bqbiol:isVersionOf>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/ec-code/2.7.12.2"/>
                  <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0006468"/>
                  <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0004708"/>
                </rdf:Bag>
              </bqbiol:isVersionOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
              <listOfReactants>
          <speciesReference species="MAPKMEKpp" metaid="_572241"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="MAPKp" metaid="_572253"/>
          <speciesReference species="MEKpp" metaid="_572265"/>
        </listOfProducts>
        <kineticLaw metaid="_572277">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> k7 </ci>
              <ci> MAPKMEKpp </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="k7" metaid="_972075" value="0.1"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="Reaction22" name="binding of MAPK-P and MAPK phosphatase" metaid="_192122" reversible="false">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_192122">
              <bqbiol:isVersionOf>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0051019"/>
                </rdf:Bag>
              </bqbiol:isVersionOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
              <listOfReactants>
          <speciesReference species="MAPKp" metaid="_572289"/>
          <speciesReference species="MAPKPH" metaid="_572301"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="MAPKpMAPKPH" metaid="_572313"/>
        </listOfProducts>
        <kineticLaw metaid="_572325">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> a8 </ci>
              <ci> MAPKp </ci>
              <ci> MAPKPH </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="a8" metaid="_972077" value="5"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="Reaction23" name="dissociation of MAPK-P_MAPKPase" metaid="_192142" reversible="false">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_192142">
              <bqbiol:isVersionOf>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0043241"/>
                </rdf:Bag>
              </bqbiol:isVersionOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
              <listOfReactants>
          <speciesReference species="MAPKpMAPKPH" metaid="_572337"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="MAPKp" metaid="_572349"/>
          <speciesReference species="MAPKPH" metaid="_572362"/>
        </listOfProducts>
        <kineticLaw metaid="_572374">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> d8 </ci>
              <ci> MAPKpMAPKPH </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="d8" metaid="_972079" value="0.4"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="Reaction24" name="dephosphorylation of MAPK-P" metaid="_192162" reversible="false">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_192162">
              <bqbiol:isVersionOf>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/ec-code/3.1.3.16"/>
                  <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0006470"/>
                </rdf:Bag>
              </bqbiol:isVersionOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
              <listOfReactants>
          <speciesReference species="MAPKpMAPKPH" metaid="_572386"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="MAPK" metaid="_572398"/>
          <speciesReference species="MAPKPH" metaid="_572411"/>
        </listOfProducts>
        <kineticLaw metaid="_572423">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> k8 </ci>
              <ci> MAPKpMAPKPH </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="k8" metaid="_972081" value="0.1"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="Reaction25" name="binding of MAPK-P and MEK-PP" metaid="_192182" reversible="false">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_192182">
              <bqbiol:isHomologTo>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/reactome/REACT_495"/>
                  <rdf:li rdf:resource="http://identifiers.org/reactome/REACT_1780"/>
                </rdf:Bag>
              </bqbiol:isHomologTo>
              <bqbiol:isVersionOf>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0051019"/>
                  <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0031434"/>
                </rdf:Bag>
              </bqbiol:isVersionOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
              <listOfReactants>
          <speciesReference species="MAPKp" metaid="_572435"/>
          <speciesReference species="MEKpp" metaid="_572447"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="MAPKpMEKpp" metaid="_572459"/>
        </listOfProducts>
        <kineticLaw metaid="_572471">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> a9 </ci>
              <ci> MAPKp </ci>
              <ci> MEKpp </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="a9" metaid="_972083" value="20"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="Reaction26" name="dissociation of MAPK-P_MEK-PP" metaid="_192203" reversible="false">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_192203">
              <bqbiol:isVersionOf>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0043241"/>
                </rdf:Bag>
              </bqbiol:isVersionOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
              <listOfReactants>
          <speciesReference species="MAPKpMEKpp" metaid="_572483"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="MAPKp" metaid="_572495"/>
          <speciesReference species="MEKpp" metaid="_572507"/>
        </listOfProducts>
        <kineticLaw metaid="_572519">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> d9 </ci>
              <ci> MAPKpMEKpp </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="d9" metaid="_972085" value="0.6"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="Reaction27" name="phosphorylation of MAPK-P" metaid="_192223" reversible="false">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_192223">
              <bqbiol:isVersionOf>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/ec-code/2.7.12.2"/>
                  <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0000187"/>
                  <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0006468"/>
                  <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0004708"/>
                </rdf:Bag>
              </bqbiol:isVersionOf>
              <bqbiol:isHomologTo>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/reactome/REACT_136"/>
                  <rdf:li rdf:resource="http://identifiers.org/reactome/REACT_2247"/>
                </rdf:Bag>
              </bqbiol:isHomologTo>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
              <listOfReactants>
          <speciesReference species="MAPKpMEKpp" metaid="_572531"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="MAPKpp" metaid="_572543"/>
          <speciesReference species="MEKpp" metaid="_572555"/>
        </listOfProducts>
        <kineticLaw metaid="_572567">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> k9 </ci>
              <ci> MAPKpMEKpp </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="k9" metaid="_972087" value="0.1"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="Reaction28" name="binding of MAPK-PP and MAPK phosphatase" metaid="_192243" reversible="false">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_192243">
              <bqbiol:isVersionOf>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0051019"/>
                </rdf:Bag>
              </bqbiol:isVersionOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
              <listOfReactants>
          <speciesReference species="MAPKPH" metaid="_572579"/>
          <speciesReference species="MAPKpp" metaid="_572591"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="MAPKppMAPKPH" metaid="_572603"/>
        </listOfProducts>
        <kineticLaw metaid="_572615">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> a10 </ci>
              <ci> MAPKPH </ci>
              <ci> MAPKpp </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="a10" metaid="_972089" value="5"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="Reaction29" name="dissociation of MAPK-PP_MAPKPase" metaid="_192262" reversible="false">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_192262">
              <bqbiol:isVersionOf>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0043241"/>
                </rdf:Bag>
              </bqbiol:isVersionOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
              <listOfReactants>
          <speciesReference species="MAPKppMAPKPH" metaid="_572627"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="MAPKPH" metaid="_572639"/>
          <speciesReference species="MAPKpp" metaid="_572651"/>
        </listOfProducts>
        <kineticLaw metaid="_572663">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> d10 </ci>
              <ci> MAPKppMAPKPH </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="d10" metaid="_972091" value="0.4"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="Reaction30" name="dephosphorylation of MAPK-PP" metaid="_192283" reversible="false">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_192283">
              <bqbiol:isVersionOf>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/ec-code/3.1.3.16"/>
                  <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0006470"/>
                  <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0000188"/>
                </rdf:Bag>
              </bqbiol:isVersionOf>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
              <listOfReactants>
          <speciesReference species="MAPKppMAPKPH" metaid="_572675"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="MAPKp" metaid="_572688"/>
          <speciesReference species="MAPKPH" metaid="_572700"/>
        </listOfProducts>
        <kineticLaw metaid="_572713">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> k10 </ci>
              <ci> MAPKppMAPKPH </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="k10" metaid="_972093" value="0.1"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
    </listOfReactions>
  </model>
</sbml>